Biological age (BA) and the influence of physiological, genetic, and epigenetic states
Sala Manuel de Terán, IEGD-CCHS-CSIC, Madrid
June 8, 2023
In this presentation we show results of a broad spectrum of BA outcome-dependent values related to mortality that are derived from several biological markers including those from physiological states (e.g., blood pressure and cholesterol levels), epiclocks (e.g., GrimAge), and telomere length. The presentation is organized around two distinct tasks: (a) generalizing and fine-tuning an existing structural equation model (SEM) to assess adult BA that reflects different physiological systems; and (b) compare BA estimates derived from biomarkers and/or epigenetic domains that are trained on multiple health outcomes reflecting different physiological systems. We will use a nationally representative longitudinal dataset fielded in the US (HRS) which contains information on older adult health indicators and mortality follow-up.
his research focuses on the demography of health and aging. He has written on health patterns and trends in low- and middle-income countries; on aging in high-income countries including issues about compression of morbidity; on the links between early life experiences and late life outcomes; as well as on biomarker data from Mexico to study physiological patterns of health and their link with sociodemographic factors. Dr. Beltrán-Sánchez is also Associate Director of the UCLA California Center for Population Research (CCPR) and co-director of the T32 training grant at CCPR.