Biological age and the microbiome
Sala Manuel de Terán, IEGD-CCHS-CSIC, Madrid
June 15, 2023
In this presentation we propose the formulation of an alternative biological clock (BA) that takes into account indicators from the microbiome (richness, evenness, and deviant taxa) as additional set of indicators for a domain not yet included in extant clocks. We will use data from the Survey of the Health of Wisconsin (SHOW) that has been collected annually since 2008 and it is representative of residents in the State of Wisconsin in the US. We use a structural equation model (SEM) to fully formalize the relations between a latent trait, BA, and observables such as chronological age (CA), biomarkers, epigenetic domains assessed by multiple epigenetic clocks, and the microbiome.
his research focuses on the demography of health and aging. He has written on health patterns and trends in low- and middle-income countries; on aging in high-income countries including issues about compression of morbidity; on the links between early life experiences and late life outcomes; as well as on biomarker data from Mexico to study physiological patterns of health and their link with sociodemographic factors. Dr. Beltrán-Sánchez is also Associate Director of the UCLA California Center for Population Research (CCPR) and co-director of the T32 training grant at CCPR.